000			02151nam a22002297a 4500
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005			20251124152556.0
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040			_aNISER LIBRARY _beng _cNISER LIBRARY
082			_a616.8 _bBAS-N
100			_aBasu, Sumela
245			_aNeurochemical characterization and regulation of CART-containing neural pathways
260			_aBhubaneswar : _bNISER, _c2025.
300			_axi, 308 pages
520			_aNeuropeptide CART is highly expressed in the CNS and is known for its remarkable potential to reconfigure neural circuits for behavioral demands. The functional significance of CART and how it operates the neural circuits to drive behavior are poorly understood. I explored the neurochemicals and signaling systems employed by CART neurons, determined the mechanism through which CART-containing systems drive behavior, and identified the conserved CARTergic neuroanatomical substrates. Three subtypes of CART neurons were observed in the hypothalamus. Secretagogin, highly expressed in the entopeduncular CART neurons, mediates the effect of insulin. CART drives the nigrostriatal DA pathway and motor coordination via the activation of TRPV2. Although CART is highly expressed in each node of the aggression circuit in male as well as female rats, a subset of CART neurons in the hypothalamic attack area drives maternal but not inter-male aggression. CART peptides and the neuroanatomy of CART-containing elements in the brain showed conserved features. Unlike mammals, CART neurons were found in two distinct subdivisions in the arcuate nucleus of a reptile. This study identifies a novel role of CART in driving aggressive actions. CART may influence neural circuits and behavior directly or via modulation of the DA-/glutamatergic pathways, and may serve as a preferred central regulator in the CNS across vertebrates.
650			_aCART (Neuropeptides)
650			_aNeuropeptides _xPhysiological effect
650			_aNeurotransmitters _xRegulation
700			_aSingru, Praful _4Guide
856			_uhttps://idr.niser.ac.in/jspui/handle/123456789/1488
942			_2udc _cTHPHD
999			_c36513 _d36513