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020			_a9781849734448
040			_aNISER LIBRARY _beng _cNISER LIBRARY
082	0	0	_a615 _bGAR-N
245	0	0	_aNew applications of NMR in drug discovery and development
260			_aCambridge : _bRSC Publishing, _c2013.
300			_axvii, 565 pages : _billustrations (some color) ; _c24 cm.
490	0		_aNew developments in NMR, _x2044-253X ; _vno. 2
504			_aIncludes bibliographical references and index.
520			_aThis book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods, many of which are not yet widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and their interactions with targets. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists, pharmacologists, imaging researchers and pharmaceutical scientists, this title is invaluable at putting NMR in context within its role in drug discovery and development. This resource is essential reading for those both new and already active in these areas.
650		0	_aDrug development.
650		0	_aDrugs _xDesign.
650		0	_aNuclear magnetic resonance spectroscopy _xIndustrial applications.
650	1	2	_aDrug Discovery.
650	2	2	_aMagnetic Resonance Spectroscopy.
700	1		_aGarrido, Leoncio _eeditor
700	1		_aBeckmann, Nicolau _eeditor
856			_3Table of content _uhttps://books.rsc.org/books/edited-volume/1007/chapter/803931/Contents
856			_3Reviews _uhttps://www.goodreads.com/book/show/17166114-new-applications-of-nmr-in-drug-discovery-and-development?ref=nav_sb_ss_1_13#CommunityReviews
942			_2udc _cBK
999			_c35859 _d35859