000			02743nam a22002897a 4500
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020			_a9780128010761
040			_aNISER LIBRARY _beng _cNISER LIBRARY
082	0	0	_a615.012 _bDI-D
100	1		_aDi, Li,
245	1	0	_aDrug-like properties : _bconcepts, structure design and methods : from ADME to toxicity optimization
250			_a2nd edition.
260			_aBoston : _bAcademic Press, _c2016
300			_axx, 560 pages : _billustrations ; _c29 cm
500			_aOriginally published as: Drug-like properties / Edward H Kerns, Li Di. 2008.
504			_aIncludes bibliographical references and index.
520			_aOf the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.
650		0	_aPharmaceutical chemistry.
650		0	_aDrugs _xStructure-activity relationships.
650		0	_aDrug development.
650		0	_aDrugs _xDesign.
700	1		_aKerns, Edward H.
856			_3Reviews _uhttps://www.goodreads.com/book/show/27283231-drug-like-properties?ref=nav_sb_ss_1_13#CommunityReviews
942			_2udc _cBK
999			_c35534 _d35534