000			02162nam a22003377a 4500
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020			_a9783319777351
040			_aNISER LIBRARY _beng _cNISER LIBRARY
082			_a616-006 _bLE-H
245			_aHeterogeneity of cancer metabolism
260			_aCham : _bSpringer, _c2018
300			_axv, 183p.
490			_aAdvances in experimental medicine and biology ; _vvolume 1063
501			_aIncludes bibliographical references and index
520			_aGenetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
650			_aBiomedicine
650			_aCancer _xTreatment
650			_aCancer cells _xMetabolism
650			_aCancer cells _xMolecular aspects
650			_aCancer research
650			_aEpigenetics and oncometabolites
650			_aGlutamine metabolism
650			_aMedical _xOncology
700			_aLe, Anne _eed.
856			_3Table of contents _uhttps://link.springer.com/content/pdf/bfm:978-3-319-77736-8/1
856			_3Reviews _uhttps://www.goodreads.com/book/show/38512895-the-heterogeneity-of-cancer-metabolism#CommunityReviews
856			_3Second edition _uhttps://link.springer.com/book/10.1007/978-3-030-65768-0
942			_2udc _cBK
999			_c35383 _d35383