000			02010nam a22002537a 4500
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005			20241112155349.0
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020			_a9780128095522
040			_aNISER LIBRARY _beng _cNISER LIBRARY
082			_a616-006 _bSAL-E
245			_aEpigenetic mechanisms in cancer
260			_aLondon : _bAcademic Press, _c2018
300			_axii, 380 pages : _billustrations (chiefly color) ;
490			_aTranslational epigenetics series ; _vvolume 3
504			_aIncludes bibliographical references at the end of each chapters and index.
520			_aEpigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
521			_aResearchers, early clinicians and advanced students investigating cancer at the genetic level
650			_aCancer _xGenetic aspects.
650			_aEpigenesis, Genetic
700			_aSaldanha, Sabita _eed.
856			_3Reviews _uhttps://www.goodreads.com/book/show/39117490-epigenetic-mechanisms-in-cancer?ref=nav_sb_ss_1_31#CommunityReviews
942			_2udc _cBK
999			_c35381 _d35381