000			04865cam a2200661Ia 4500
001			ocn162129974
003			OCoLC
005			20141103172223.0
006			m o d
007			cr cn|||||||||
008			070802s2006 enka ob 001 u eng d
040			_aOPELS _beng _cOPELS _dOKU _dOCLCQ _dGBVCP _dOCLCF _dOCLCE
019			_a607647034
020			_a9780124192393
020			_a0124192394
029	1		_aNZ1 _b12434337
029	1		_aDEBBG _bBV039831374
029	1		_aGBVCP _b573155674
035			_a(OCoLC)162129974 _z(OCoLC)607647034
037			_a102148:102166 _bElsevier Science & Technology _nhttp://www.sciencedirect.com
042			_adlr
050		4	_aRC566 _b.K66 2006eb
060		0	_a2006 A-487
060		0	_aWM 270
082	0	4	_a616.86 _222
049			_aTEFA
100	1		_aKoob, George F.
245	1	0	_aNeurobiology of addiction _h[electronic resource] / _cGeorge F. Koob, Michel Le Moal.
260			_aLondon : _bElsevier Academic, _cc2006.
300			_a1 online resource (viii, 490 p.) : _bill. (some col.)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aWhat is addiction? -- Animal models of drug addiction -- Psychostimulants -- Opioids -- Alcohol -- Nicotine -- Cannabinoids -- Imaging -- Neurobiological theories of addiction -- Drug addiction : transition from neuroadaptation to pathophysiology.
520			_aNeurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching.
505	0		_aPreface -- Acknowledgments -- 1. What is addiction -- 2. Animal models of drug addiction -- 3 Psychostimulants -- 4. Opioids -- 5. Alcohol -- 6. Nicotine -- 7. Cannabinoids -- 8. Imaging -- 9. Neurobiological theories of addiction -- 10. Drug addiction: transition from neuroadaptation to pathophysiology -- Appendix 1. Psychostimulants -- Appendix 2. Opioids -- Appendix 3. Alcohol -- Appendix 4. Nicotine -- Appendix 5. Cannabinoids -- Index.
588			_aDescription based on print version record.
506			_3Use copy _fRestrictions unspecified _2star _5MiAaHDL
533			_aElectronic reproduction. _b[S.l.] : _cHathiTrust Digital Library, _d2010. _5MiAaHDL
538			_aMaster and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. _uhttp://purl.oclc.org/DLF/benchrepro0212 _5MiAaHDL
583	1		_adigitized _c2010 _hHathiTrust Digital Library _lcommitted to preserve _2pda _5MiAaHDL
650		0	_aDrug addiction.
650		0	_aNeurobiology.
650		0	_aNeuropharmacology.
650	1	2	_aSubstance-Related Disorders _xphysiopathology.
650	2	2	_aBehavior, Addictive _xphysiopathology.
650	2	2	_aNeurobiology.
650		7	_aDrug addiction. _2fast _0(OCoLC)fst01430217
650		7	_aNeurobiology. _2fast _0(OCoLC)fst01036315
650		7	_aNeuropharmacology. _2fast _0(OCoLC)fst01036458
655		4	_aElectronic books.
700	1		_aLe Moal, Michel.
776	0	8	_iPrint version: _aKoob, George F. _tNeurobiology of addiction. _dLondon : Elsevier Academic, c2006 _z0124192394 _z9780124192393 _w(OCoLC)62614717
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780124192393
942			_cEB
994			_aC0 _bTEF
999			_c21717 _d21717