| 000 | 05268cam a2200697Ia 4500 | ||
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| 001 | ocn272382250 | ||
| 003 | OCoLC | ||
| 005 | 20141103172212.0 | ||
| 006 | m d | ||
| 007 | cr cn||||||||| | ||
| 008 | 081117s2008 ne a ob 001 0 eng d | ||
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| 019 |
_a233578043 _a239300330 _a646740873 |
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| 020 | _a9780444528247 | ||
| 020 | _a0444528245 | ||
| 020 | _a9780080570327 (electronic bk.) | ||
| 020 | _a0080570321 (electronic bk.) | ||
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_a(OCoLC)272382250 _z(OCoLC)233578043 _z(OCoLC)239300330 _z(OCoLC)646740873 |
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| 037 |
_a114030:114121 _bElsevier Science & Technology _nhttp://www.sciencedirect.com |
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_aRC271.C5 _bA94 2008eb |
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| 082 | 0 | 4 |
_a616.994061 _222 |
| 049 | _aTEFA | ||
| 100 | 1 | _aAvenda�no, Carmen. | |
| 245 | 1 | 0 |
_aMedicinal chemistry of anticancer drugs _h[electronic resource] / _cCarmen Avenda�no and J. Carlos Men�endez. |
| 250 | _a1st ed. | ||
| 260 |
_aAmsterdam ; _aBoston : _bElsevier, _c2008. |
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| 300 |
_a1 online resource (xv, 442 p.) : _bill. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 520 | _aAntitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature. | ||
| 505 | 0 | _a1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10. Other approaches to targeted therapy -- 11. Drug targeting in anticancer chemotherapy -- 12. Resistance to antitumour agents and drugs that modulate it -- 13. Cancer chemoprevention. | |
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aIntroduction -- Antimetabolites -- Anticancer drugs that inhibit hormone action -- Anticancer drugs acting via radical species, photosensitizers and photodynamic therapy of cancer -- DNA alkylating agents -- Alkylating and non-alkylating compounds interacting with the DNA minor groove -- DNA intercalators and topoisomerase inhibitors -- Anticancer drugs targeting tubulin and microtubules -- Drugs that inhibit signalling pathways for tumor cell growth and proliferation -- Other approaches to targeted therapy -- Drug targeting in anticancer chemotherapy -- Drugs that modulate resistance to antitumor agents -- Cancer chemoprevention. | |
| 588 | _aDescription based on print version record. | ||
| 650 | 0 |
_aCancer _xChemotherapy. |
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| 650 | 0 |
_aDrugs _xDesign. |
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| 650 | 0 | _aPharmaceutical chemistry. | |
| 650 | 7 |
_aCancer _xChemotherapy. _2fast _0(OCoLC)fst00845327 |
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| 650 | 7 |
_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790 |
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| 650 | 7 |
_aPharmaceutical chemistry. _2fast _0(OCoLC)fst01060115 |
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| 650 | 7 |
_aMEDICAL _xOncology. _2bisacsh |
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| 650 | 7 |
_aHEALTH & FITNESS _xDiseases _xCancer. _2bisacsh |
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| 655 | 4 | _aElectronic books. | |
| 700 | 1 |
_aMen�endez, J. Carlos _q(Jos�e Carlos) |
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| 776 | 0 | 8 |
_iPrint version: _aAvenda�no, Carmen. _tMedicinal chemistry of anticancer drugs. _b1st ed. _dAmsterdam ; Boston : Elsevier, 2008 _z9780444528247 _z0444528245 _w(OCoLC)227271605 |
| 856 | 4 | 0 |
_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780444528247 |
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_aEBSCOhost _bEBSC _n227593 |
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_aYBP Library Services _bYANK _n2816701 |
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