000			04476cam a2200565Ia 4500
001			ocn228148277
003			OCoLC
005			20141103172212.0
006			m o d
007			cr cn|||||||||
008			080516s2007 enkaf ob 001 0 eng d
040			_aOPELS _beng _cOPELS _dOCLCQ _dOCLCF _dCHVBK
020			_a9780123694485
020			_a0123694485
029	1		_aNZ1 _b12541708
029	1		_aDKDLA _b820120-katalog:000577709
029	1		_aDEBSZ _b405318618
029	1		_aCHVBK _b122271564
029	1		_aCHDSB _b005985912
035			_a(OCoLC)228148277
037			_a114525:114618 _bElsevier Science & Technology _nhttp://www.sciencedirect.com
050		4	_aRS431.A64 _bC36 2008eb
060		4	_a2008 A-287
060		4	_aQV 269 _bN397c 2008
082	0	4	_a616.994061 _222
049			_aTEFA
245	0	0	_aCancer drug design and discovery _h[electronic resource] / _cedited by Stephen Neidle.
250			_a1st ed.
260			_aNew York, NY : _bAcademic Press, _c2008.
300			_a1 online resource (xv, 473 p., [27] p. of plates) : _bill. (some col.)
520			_aThe ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry, and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories.
505	0		_aSection I. Basic Principles -- 1. Modern cancer drug discovery: Integrating targets, technologies and treatments -- 2. Preclinical pharmacology and in vivo models -- 3. Clinical trial designs for more rapid proof-of-principle and approval -- Section II. Methodology -- 4. Structural biology and anticancer drug design -- 5. Natural product chemistry and cancer drug discovery -- 6. Pharmacokinetics & ADME optimization in drug discovery -- Section III. Drugs in the clinic and laboratory -- 7. Temozolomide: from cytotoxic to molecularly-targeted agent -- 8. Camptothecins for drug design, cancer cell death and gene targeting -- 9. Targeting thymidylate synthase by antifolate drugs for the treatment of cancer -- Section IV. New Agents -- 10. Targeting inactive kinases: structure as a foundation for cancer drug discovery -- 11. Cell cycle inhibitors in cancer: current status and future directions -- 12. Inhibition of DNA repair as a therapeutic target -- 13. Heat shock protein-90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways -- 14. Heat shock protein-90-directed therapeutics and target validation -- 15. Inhibitors of tumour angiogenesis -- 16. The biology and oncology of RAFERK signalling P53 as a therapeutic target -- Section V. The reality of cancer drugs in the clinic -- 17. Cancer drug resistance -- 18. Failure Modes in Anticancer Drug Discovery and Development.
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record.
650		0	_aAntineoplastic agents _xDevelopment.
650		0	_aAntineoplastic agents _xDesign.
650		0	_aCancer _xChemotherapy.
650		7	_aAntineoplastic agents _xDesign. _2fast _0(OCoLC)fst00810598
650		7	_aAntineoplastic agents _xDevelopment. _2fast _0(OCoLC)fst00810599
650		7	_aCancer _xChemotherapy. _2fast _0(OCoLC)fst00845327
650		2	_aAntineoplastic Agents.
650		2	_aDrug Design.
650		2	_aNeoplasms _xdrug therapy.
655		4	_aElectronic books.
700	1		_aNeidle, Stephen.
776	0	8	_iPrint version: _tCancer drug design and discovery. _b1st ed. _dNew York, NY : Academic Press, 2008 _z9780123694485 _z0123694485 _w(OCoLC)154760280
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780123694485
942			_cEB
994			_aC0 _bTEF
999			_c20999 _d20999