000			06726cam a2200745Ia 4500
001			ocn162130225
003			OCoLC
005			20141103172211.0
006			m o d
007			cr cn|||||||||
008			070802s2006 ne a ob 001 0 eng d
040			_aOPELS _beng _cOPELS _dBAKER _dOPELS _dOCLCQ _dN$T _dE7B _dNRU _dOCLCQ _dREDDC _dOCLCQ _dTULIB _dOCLCO _dOCLCQ _dOPELS _dNLGGC _dCHVBK
019			_a123453129 _a154703295 _a647616745 _a779917399
020			_a9780444511584
020			_a044451158X
020			_a9780080463834 (electronic bk.)
020			_a0080463835 (electronic bk.)
020			_z008046355X
029	1		_aNZ1 _b12434453
029	1		_aAU@ _b000048130535
029	1		_aDEBBG _bBV039829046
029	1		_aAU@ _b000051557986
029	1		_aNLGGC _b380877309
029	1		_aCHVBK _b166988847
029	1		_aCHBIS _b005663615
035			_a(OCoLC)162130225 _z(OCoLC)123453129 _z(OCoLC)154703295 _z(OCoLC)647616745 _z(OCoLC)779917399
037			_a109762:109810 _bElsevier Science & Technology _nhttp://www.sciencedirect.com
050		4	_aQP187.3.M64 _bA38 v.5eb
060		4	_aW1 _bAD6823 v.5 2006
060		4	_aWK 810 _bN5329 2006
072		7	_aHEA _x039050 _2bisacsh
082	0	4	_a616.46207 _222
049			_aTEFA
245	0	0	_aNew transcription factors and their role in diabetes and therapy _h[electronic resource] / _ceditor, Jacob E. Friedman.
250			_a1st ed.
260			_aAmsterdam ; _aBoston : _bElsevier, _c2006.
300			_a1 online resource (xii, 309 p.) : _bill.
490	1		_aAdvances in molecular and cellular endocrinology ; _vv. 5
520			_aThis book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity *Underscores the clinical relevance of transcription factors *Provides a valuable overview of the current status of the field.
505	0		_a1. PPARs as therapeutic targets for treating diabetes and insulin resistance -- 2. Genetic regulators of human obesity and diabetes -- 3. NF-kb, insulin resistance and the actions of salicylates -- 4. Wnt signaling and C/EBPs role in adipogenesis -- 5. Regulation of hepatic gluconeogenesis C/EPBs -- 6. Forkhead proteins and regulation of hepatic gene expression -- 7. Control of mitochondrial biogenesis through PGC-1 -- 8. Regulation of PGC-1 in humans in insulin resistance and diabetes: Functional implications -- 9. FOXC2 controls resistance to obesity and Type II diabetes -- 10. SREB-1C regulation of nutrient homeostasis and lipid accumulation -- 11. GATA proteins as molecular gatekeeprs of the adipocyte -- 12. Diabetes regulation of gene expression by CREB -- 13. Molecular etiologies of MODY and other early-onset forms of diabetes -- 14. Liver X receptors as potential drug targets for Diabetes and its disorders -- 15. The potential therapeutic use of PPAR beta/delta agonists in lipid and glucose homeostasis -- 16. Influences of new PPAR insulin sensitizers on the metabolic syndrome in Rhesus Monkeys -- 17. PPARgamma and metabolism: Insights from the study of human genetic variants.
504			_aIncludes bibliographical references and index.
505	0		_aTranscription factor genes in type 2 diabetes / by M.N. Weedon, A.T. Hattersley & T.M. Frayling -- PPAR[gamma], a key therapeutic target in the metabolic syndrome-unique insights derived from the study of human genetic variants / by C.S. Mitchell & M. Gurnell -- PPAR[delta]: emerging therapeutic potential of novel agonists in lipid and glucose homeostasis / by U. Dressel & G.E.O. Muscat -- Liver X receptors as potential drug targets for diabetes and its disorders / by K.R. Steffenson -- SREBP-lc regulation of nutrient homeostasis and lipid accumulation / by P. Ferr�e ... [et al.] -- The adipocyte and adipose tissue as endocrine organs: impact on the insulin resistance phenotype / by R.R. Henry ... [et al.] -- FOXC2 in the adipocyte / by S. Enerb�ack -- Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors / by I. Gerin, H.D. Cha & O.A. MacDougald -- GATA proteins as molecular gatekeepers of adipogenesis / by J. Tsai, Q. Tong & G.S. Hotamisligil -- Forkhead proteins and the regulation of hepatic gene expression / by A. Barthel, S. Herzig & D. Schmoll -- Disruption of CREB regulated of gene expression in diabetes / by J.E.B. Reusch, P.A. Watson & S. Pugazhenthi -- Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: functional implications / by J. Pihlajam�aki & M.E. Patti -- Hepatic CCAAT/enhancer binding protein [beta] (C/EBP[beta]): engineer of diabetes, obesity, and inflammatory disease processes / by J.M. Schroeder-Gloeckler, S.M. Rahman & J.E. Friedman -- Insulin resistance, inflammation, and the IKK/I[kappa]B/NF-[kappa]B pathway by B.A. Bhatt & R.M. O'Doherty.
588			_aDescription based on print version record.
650		0	_aTranscription factors.
650		0	_aDiabetes _xGenetic factors.
650		0	_aDiabetes _xPathophysiology.
650		6	_aDiab�ete _xPhysiopathologie.
650		6	_aFacteurs de transcription.
650		6	_aOb�esit�e _xPhysiopathologie.
650		7	_aHEALTH & FITNESS _xDiseases _xDiabetes. _2bisacsh
650		4	_aDiabetes Mellitus, Type 2 _xGenetics.
650		4	_aDiabetes mellitus, Type 2 _xPhysiopathology.
650		2	_aDiabetes Mellitus, Type 2.
650		2	_aTranscription Factors.
655		4	_aElectronic books.
700	1		_aFriedman, Jacob E.
776	0	8	_iPrint version: _tNew transcription factors and their role in diabetes and therapy. _b1st ed. _dAmsterdam ; Boston : Elsevier, 2006 _z044451158X _z9780444511584 _w(OCoLC)84712688
830		0	_aAdvances in molecular and cellular endocrinology ; _vv. 5.
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780444511584
938			_aBaker & Taylor _bBKTY _c139.95 _d.00 _i044451158X _n0006308408 _sactive
938			_aebrary _bEBRY _nebr10150482
938			_aEBSCOhost _bEBSC _n173500
942			_cEB
994			_aC0 _bTEF
999			_c20922 _d20922