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Non-viral vectors for gene therapy. Part II [electronic resource] / edited by Leaf Huang, Mien-chie Hung, Ernst Wagner.

Contributor(s): Huang, Leaf | Hung, Mien-chie | Wagner, Ernst, 1960-Material type: TextTextSeries: Advances in genetics ; v. 54.Publication details: Amsterdam ; Boston : Elsevier Academic Press, c2005. Edition: 2nd edDescription: 1 online resource (1 v.) : ill. (some col.)ISBN: 0080456138 (electronic bk.); 9780080456133 (electronic bk.); 0120176548 (electronic bk.); 9780120176540 (electronic bk.)Other title: Nonviral vectors for gene therapySubject(s): Gene therapy | Genetic vectors | Genetic transformation | Genetic Vectors -- therapeutic use | Gene Therapy -- methods | Gene Transfer Techniques | Transformation, Genetic | HEALTH & FITNESS -- Diseases -- Genetic | MEDICAL -- Genetics | Gentherapie | Vectoren (parasitologie) | Gene therapy | Genetic transformation | Genetic vectorsGenre/Form: Electronic books.Additional physical formats: Print version:: Non-viral vectors for gene therapy. Part II.DDC classification: 616/.042 LOC classification: RB155.8 | .N66eb pt. 2Online resources: ScienceDirect
Contents:
The mechanism of naked DNA uptake and expression / Jon A. Wolff and Vladimir Budker. Targeted delivery of therapeutic oligonucleotides to pulmonary circulation / Annette Wilson ... [et al.] Naked DNA for liver gene transfer / Feng Liu and Pradeep Tyagi. Hydrodynamic delivery / Mohammed S. Al-Dosari, Joseph E. Knapp, and Dexi Liu. Electric pulse-mediated gene delivery to various animal tissues / Lluis M. Mir ... [et al.] In vivo application of RNA interference: from functional genomics to therapeutics / Patrick Y. Lu, Frank Xie, and Martin C. Woodle. A novel gene expression system: non-viral gene transfer for hemophilia as model systems / Carol H. Miao. Site-specific integration with [phi]C31 integrase for prolonged expression of therapeutic genes / Daniel S. Ginsburg and Michele P. Calos. Sleeping Beauty transposon-mediated gene therapy for prolonged expression / Perry B. Hackett ... [et al.] Cancer-specific gene therapy / Hui-Wen Lo, Chi-Ping Day, and Mien-Chie Hung. DNA vaccine / Zhengrong Cui. Airway gene therapy / Jane C. Davies and Eric W.F.W. Alton. Non-viral vector as vaccine carrier / Weihsu Claire Chen and Leaf Huang. Non-viral vectors for gene therapy: clinical trials in cardiovascular disease / Pinak B. Shah and Douglas W. Losordo.
Summary: The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therap.
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Includes bibliographical references and indexes.

The mechanism of naked DNA uptake and expression / Jon A. Wolff and Vladimir Budker. Targeted delivery of therapeutic oligonucleotides to pulmonary circulation / Annette Wilson ... [et al.] Naked DNA for liver gene transfer / Feng Liu and Pradeep Tyagi. Hydrodynamic delivery / Mohammed S. Al-Dosari, Joseph E. Knapp, and Dexi Liu. Electric pulse-mediated gene delivery to various animal tissues / Lluis M. Mir ... [et al.] In vivo application of RNA interference: from functional genomics to therapeutics / Patrick Y. Lu, Frank Xie, and Martin C. Woodle. A novel gene expression system: non-viral gene transfer for hemophilia as model systems / Carol H. Miao. Site-specific integration with [phi]C31 integrase for prolonged expression of therapeutic genes / Daniel S. Ginsburg and Michele P. Calos. Sleeping Beauty transposon-mediated gene therapy for prolonged expression / Perry B. Hackett ... [et al.] Cancer-specific gene therapy / Hui-Wen Lo, Chi-Ping Day, and Mien-Chie Hung. DNA vaccine / Zhengrong Cui. Airway gene therapy / Jane C. Davies and Eric W.F.W. Alton. Non-viral vector as vaccine carrier / Weihsu Claire Chen and Leaf Huang. Non-viral vectors for gene therapy: clinical trials in cardiovascular disease / Pinak B. Shah and Douglas W. Losordo.

The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therap.

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