TY  - BOOK
AU  - Conn,P.Michael
TI  - G protein coupled receptors
T2  - Methods in enzymology
SN  - 9780123918727 (electronic bk.)
AV  - QP552.G16 
U1  - 572.696 23
PY  - 2013///
CY  - San Diego, Calif.
PB  - Academic Press/Elsevier
KW  - G proteins
KW  - Receptors
KW  - Receptors, G-Protein-Coupled
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and indexes; Expression of GPCRs in Pichia pastoris for structural studies -- Conformational ensemble view of G protein-couples receptors and the effect of mutations and ligand binding -- Structural evolution of G-protein-coupled receptors: a sequence space approach -- Directed evolution of G-protein-coupled receptors for high functional expression and detergent stability -- The role of hydrophobic amino acids in the structure and function of the Rhodopsin family of G protein-coupled receptors -- Structure of [beta]-adrenergic receptors -- Advances in methods to characterize ligand-induced ionic lock and Rotamer toggle molecular switch in G protein-coupled receptors -- Crystallogenesis of adenosine A2A receptor-T4 lysozyme fusion protein: a practical route for the structure -- Probing GPCR structure: adenosine and P2Y nucleotide receptors -- Strategies for studying the ligand binding site of GPCRs: photoaffinity labeling of the VPAC1 receptor, a prototype of class B GPCRs -- Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans -- Expression, purification, and structural analysis of intracellular C-termini from metabotropic glutamate receptors -- Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling -- Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers -- Alternative mRNA splicing of G protein-coupled receptors -- Functional residues essential for the activation of the C1 Cannabinoid receptor
N2  - This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain
UR  - http://www.sciencedirect.com/science/book/9780123918611
UR  - http://www.sciencedirect.com/science/bookseries/00766879/520
ER  -