TY  - BOOK
AU  - Hopwood,D.A.
TI  - Complex enzymes in microbial natural product biosynthesis
T2  - Methods in enzymology,
SN  - 9780080923352 (electronic bk.)
AV  - QP601 .M49eb v. 458
U1  - 572/.45 22
PY  - 2009///
CY  - Amsterdam, Boston, London, San Diego, Calif
PB  - Elsevier, Academic Press
KW  - Biosynthesis
KW  - Peptides
KW  - Synthesis
KW  - Carbohydrates
KW  - biosynthesis
KW  - Biological Products
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and index
N2  - Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. * Gathers tried and tested methods and techniques from top players in the field. * In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides. * Provides an extremely useful reference for the experienced research scientist
UR  - http://www.sciencedirect.com/science/book/9780123745880
UR  - http://www.sciencedirect.com/science/bookseries/00766879/458
ER  -