TY  - BOOK
AU  - Johnson,Michael L.
AU  - Holt,Jo M.
AU  - Ackers,Gary K.
TI  - Biothermodynamics
T2  - Methods in enzymology,
SN  - 9780123860040 (electronic bk.)
AV  - QP601 .M49eb v. 492
U1  - 574.1925 22
PY  - 2011///
CY  - Amsterdam, Netherlands, Boston, Mass.
PB  - Elsevier/Academic Press
KW  - Thermodynamics
KW  - Protein binding
KW  - Protein-protein interactions
KW  - Ligands (Biochemistry)
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - fast
KW  - Protein Binding
KW  - Protein Array Analysis
KW  - Ligands
KW  - Electronic books
N1  - Includes bibliographical references and indexes; A thermodynamic approach for the targeting of nucleic acid structures using their complementary single strands -- Thermodynamics of biological processes -- Protein stability in the presence of cosolutes -- Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell [alpha]-defensin cryptdin-4 -- Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery -- Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes -- Non-B conformations of CAG repeats using 2-aminopurine -- Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo -- Strategies for the thermodynamic characterization of linked binding/local folding reactions within the native state application to the lid domain of adenylate kinase from Escherichia coli -- Fluorescence-detected sedimentation in dilute and highly concentrated solutions
N2  - The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. * Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules * Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research * Offers step-by-step lab instructions, including necessary equipment, from a global research community
UR  - http://www.sciencedirect.com/science/book/9780123860033
UR  - http://www.sciencedirect.com/science/bookseries/00766879/492
ER  -