TY  - BOOK
AU  - Johnson,Michael L.
AU  - Holt,Jo M.
AU  - Ackers,Gary K.
TI  - Biothermodynamics
T2  - Methods in enzymology,
SN  - 9780123812681 (electronic bk.)
AV  - QP517.T48 
U1  - 571.4 
PY  - 2011///
CY  - Amsterdam [Netherlands], Boston [Mass.]
PB  - Elsevier/Academic Press
KW  - Thermodynamics
KW  - Protein binding
KW  - Protein-protein interactions
KW  - Ligands (Biochemistry)
KW  - Protein Binding
KW  - Hemoglobins
KW  - Ligands
KW  - SCIENCE
KW  - Life Sciences
KW  - Biochemistry
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and indexes; 1; Measurement and analysis of equilibrium binding titrations : a beginner's guide; Dorothy Beckett --; 2; Macromolecular competition titration method : accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs; Wlodzimierz Bujalowksi and Maria J. Jezewska --; 3; Analysis of PKR-RNA interactions by sedimentation velocity; C. Jason Wong, Katherine Launer-Felty, and James L. Cole --; 4; Structural and thermodynamic analysis of PDZ-ligand interactions; Tyson R. Shepherd and Ernesto J. Fuentes --; 5; Thermodynamic analysis of metal ion-induced protein assembly; Andrew B. Herr and Deborah G. Conrady --; 6; Thermodynamic dissection of colicin interactions; Nicholas G. Housden and Colin Kleanthous --; 7; Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling; John E. Ladbury and Stefan T. Arold --; 8; Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase; J. Ching Lee and Petr Herman --; 9; Analysis of free energy versus temperature curves in protein folding and macromolecular interactions; Vince J. LiCata and Chin-Chi Liu --; 10; Application of the sequential n-step kinetic mechanism to polypeptide translocases; Aaron L. Lucius, Justin M. Miller, and Burki Rajendar --; 11; A coupled equilibrium approach to study nucleosome thermodynamics; Andrew J. Andrews and Karolin Luger --; 12; Quantitative methods for measuring DNA flexibility in vitro and in vivo; Justin P. Peters, Nicole A. Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahn, and L. James Maher III
N2  - The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules
UR  - http://www.sciencedirect.com/science/book/9780123812681
UR  - http://www.sciencedirect.com/science/bookseries/00766879/488
ER  -