Methods in protein design [electronic resource] / edited by Amy E. Keating.
Material type: TextSeries: Methods in enzymology ; v. 523.Publication details: San Diego, Calif. : Academic, 2013. Description: 1 online resource (xviii, 464 p.) : illISBN: 9780123946294 (electronic bk.); 0123946298 (electronic bk.)Subject(s): Protein engineering | Ejournals -- UML | SCIENCE / Biotechnology | Protein engineeringGenre/Form: Electronic books.DDC classification: 660.6/3 LOC classification: QP601 | .C733 v.523Online resources: Science Direct | ScienceDirectIncludes bibliographical references and indexes.
Computational design of novel protein binders and experimental affinity maturation -- Mining tertiary structural motifs for assessment of designability -- Computational methods for controlling binding specificity -- Flexible backbone sampling methods to model and design protein alternative conformations -- Osprey: protein design with ensembles, flexibility, and provable algorithms -- Scientific benchmarks for guiding macromolecular energy function improvement -- Molecular dynamics simulations for the ranking, evaluation, and refinement of computationally designed proteins -- Multistate protein design using CLEVER and CLASSY -- Using analyses of amino acid coevolution to understand protein structure and function -- Evolution-based design of proteins -- Protein engineering and stabilization from sequence statistics: variation and covariation analysis -- Enzyme engineering by targeted libraries -- Generation of high-performance binding proteins for pepetide motifs by affinity clamping -- Engineering fibronectin-based binding proteins by yeast surface display -- Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing -- Efficient sampling of SCHEMA chimera families to identify useful sequence elements -- Protein switch engineering by domain insertion -- Design of chimeric proteins by combination of subdomain-sized fragments -- [alpha]-helix mimicry with [alpha/beta]-peptides.
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