GTPases regulating membrane targeting and fusion [electronic resource] / edited by William E. Balch, Channing J. Der, Alan Hall.
Material type: TextSeries: Methods in enzymology ; v. 403.Publication details: Amsterdam ; Boston : Elsevier Academic Press, c2005. Description: 1 online resource (xliii, 863 p., [28] p. of plates) : ill. (some col.)ISBN: 0121828085 (electronic bk.); 9780121828080 (electronic bk.)Subject(s): Cellular control mechanisms | Enzymes | Membrane fusion | Membranes (Biology) | GTP Phosphohydrolases -- metabolism | Cell Membrane -- metabolism | Membrane Fusion | Enzymes | Cellular control mechanisms | Enzymes | Membrane fusion | Membranes (Biology)Genre/Form: Electronic books.DDC classification: 572.696 LOC classification: QP601 | .M49 vol. 403NLM classification: W1 | QU 136Other classification: 42.15 | 35.79 Online resources: ScienceDirect | ScienceDirect | Volltext Summary: Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. * Comprehensive overview of Rab GTPase phylogeny and systems biology * Identification and characterization of Rab GEFs, GAPs and effectors * General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches.Includes bibliographical references and index.
Description based on print version record.
Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This volume of MIE provides a wealth of new concepts, approaches and tools to study Rab proteins in the test tube and in living cells that will be of strong benefit to both established laboratories and new investigators in the field to elucidate Rab GTPase function in cellular development, differentiation and proliferation. * Comprehensive overview of Rab GTPase phylogeny and systems biology * Identification and characterization of Rab GEFs, GAPs and effectors * General methodologies to study Rab GTPase function in vitro and in vivo using biochemical, molecular and microscopy approaches.
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