Computer methods [electronic resource] / edited by Michael L. Johnson, Ludwig Brand.

Includes bibliographical references and indexes.

pt. A. -- Phase response curves: elucidatind the dynamics of coupled oscillators / A. Granada ... [et al.] -- Multiple ion binding equilibria, reaction kinetics, and thermodynamics in dynamic models of biochemical pathways / Kalyan C. Vinnakota ... [et al.] -- Analytical methods for the retrieval and interpretation of continuous glucose monitoring data in diabetes / Boris Kovatchev, Marc Breton, William Clarke -- Analysis of heterogeneity in molecular weight and shape by analytical ultracentrifugation using parallel distributed computing / Borries Demeler, Emre Brookes, Luitgard Nagel-Steger -- Discrete stochastic simulation methods for chemically reacting systems / Yang Cao, David C. Samuels -- Analyses for physiological and behavioral rhythmicity / Harold B. Dowse -- Computational approach for the rational design of stable proteins and enzymes; optimization of surface charge--charge interactions / Katrina L. Schweiker, George I. Makhatadze -- Efficient computation of confidence intervals for Bayesian model predictions based on multidimensional parameter space / Amber D. Smith ... [et al.] -- Analyzing enzymatic pH activity profiles and protein titration curves using structure-based pKa calculations and titration curve fitting / Jens Erik Nielsen -- Least squares in calibration: weights, nonlinearity, and other nuisances / Joel Tellinghuisen -- Evaluation and comparison of computational models / Jay I. Myung, Yun Tang, Mark A. Pitt -- Desegregating undergraduate mathematics and biology--interdisciplinary instruction with emphasis on ongoing biomedical research / Raina Robeva -- Mathematical algorithms for high-resolution DNA melting analysis / Robert Palais, Carl T. Wittwer -- Biomathematical modeling of pulsatile hormone secretion: a historical perspective / William S. Evans, Leon S. Farhy, Michael L. Johnson -- AutoDecon: a robust numerical method for the quantification of pulsatile events / Michael L. Johnson ... [et al.] -- Modeling fatigue over sleep deprivation, circadian rhythm, and caffeine with a minimal performance inhibitor model / Patrick L. Benitez ... [et al.].

Description based on print version record.

The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed. This volume, along with previous and forthcoming Computer Methods volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as applied to biomedical research. * Presents step-by-step computer methods and discusses the techniques in detail to enable their implementation in solving a wide range of problems. * Informs biomedical researchers of the modern data analysis methods that have developed alongside computer hardware *Presents methods at the "nuts and bolts" level to identify and resolve a problem and analyze what the results mean.

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