Complex enzymes in microbial natural product biosynthesis. Part B, Polyketides, aminocoumarins, and carbohydrates [electronic resource] / edited by David A. Hopwood.

Includes bibliographical references and indexes.

Introduction to polyketide biosynthesis / K.J. Weissman -- Structural enzymology of polyketide synthases / S.C. Tsai and B.D. Ames -- Fungal type I polyketide synthases / R.J. Cox and T.J. Simpson -- Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases / H. Jiang, S.R. Rajski and B. Shen -- Iterative type I polyketide synthases for enediyne core biosynthesis / G.P. Horsman, S.G. Van Lanen and B. Shen -- The DEBS paradigm for type I modular polyketide synthases and beyond / L. Katz -- Formation and characterization of acyl carrier protein-linked polyketide synthase extender units / Y.A. Chan and M.G. Thomas -- Type I polyketide synthases that require discrete acyltransferases / Y.Q. Cheng [and others] -- The enzymology of polyether biosynthesis / T. Liu, D.E. Cane and Z. Deng -- Enzymology of the polyenes pimaricin and candicidin biosynthesis / J.F. Martin and J.F. Aparicio -- Genetic analysis of nystatin and amphotericin biosynthesis / S. Zotchev and P. Caffrey -- Polyketide versatility in the biosynthesis of complex mycobacterial cell wall lipids / T. Chopra and R.S. Gokhale -- Genetic engineering to produce polyketide analogues / C.D. Reeves and E. Rodriguez -- Design and synthesis of pathway genes for polyketide biosynthesis / S. Peiru, H. Gramajo and H.G. Menzella -- Heterologous production of polyketides in bacteria / E. Rodriguez, H.G. Menzella and H. Gramajo -- In vitro analysis of type II polyketide synthase / W. Zhang and Y. Tang -- Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways / J.E. Cronan and J. Thomas -- Aminocoumarins mutasynthesis, chemoenzymatic synthesis, and metabolic engineering / L. Heide -- Enzymology of aminoglycoside biosynthesis-deduction from gene clusters / U.F. Wehmeier and W. Piepersberg -- Biosynthetic enzymes for the aminoglycosides butirosin and neomycin / F. Kudo and T. Eguchi -- Enzymatic synthesis of TDP-deoxysugars / J. White-Phillip, C.J. Thibodeaux and H.W. Liu.

Print version record.

This volume will showcase the most important chemical classes of complex enzymes, which have been an important traditional source of valuable antibiotics and other drugs.