Biothermodynamics. Part C [electronic resource] / edited by Michael L. Johnson, Jo M. Holt and Gary K. Ackers.

Contributor(s): Johnson, Michael L, 1947- | Holt, Jo M | Ackers, Gary KMaterial type: Text

TextSeries: Methods in enzymology ; v. 488.Publication details: Amsterdam [Netherlands] ; Boston [Mass.] : Elsevier/Academic Press, 2011. Edition: 1st edDescription: 1 online resource (xlv, 354 pages, [8] pages of plates) : illustrations (some color)Content type: text Media type: computer Carrier type: online resourceISBN: 9780123812681 (electronic bk.); 0123812682 (electronic bk.)Subject(s): Thermodynamics | Protein binding | Protein-protein interactions | Ligands (Biochemistry) | Protein Binding | Hemoglobins | Ligands | Thermodynamics | SCIENCE -- Life Sciences -- Biochemistry | Ligands (Biochemistry) | Protein binding | Protein-protein interactions | ThermodynamicsGenre/Form: Electronic books.Additional physical formats: Print version:: Biothermodynamics. Part C.DDC classification: 571.4 LOC classification: QP517.T48NLM classification: QU 55.9 | QU 25Online resources: ScienceDirect | ScienceDirect

Contents:

1. Measurement and analysis of equilibrium binding titrations : a beginner's guide / Dorothy Beckett -- 2. Macromolecular competition titration method : accessing thermodynamics of the unmodified macromolecule-ligand interactions through spectroscopic titrations of fluorescent analogs / Wlodzimierz Bujalowksi and Maria J. Jezewska -- 3. Analysis of PKR-RNA interactions by sedimentation velocity / C. Jason Wong, Katherine Launer-Felty, and James L. Cole -- 4. Structural and thermodynamic analysis of PDZ-ligand interactions / Tyson R. Shepherd and Ernesto J. Fuentes -- 5. Thermodynamic analysis of metal ion-induced protein assembly / Andrew B. Herr and Deborah G. Conrady -- 6. Thermodynamic dissection of colicin interactions / Nicholas G. Housden and Colin Kleanthous -- 7. Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling / John E. Ladbury and Stefan T. Arold -- 8. Structural and functional energetic linkages in allosteric regulation of muscle pyruvate kinase / J. Ching Lee and Petr Herman -- 9. Analysis of free energy versus temperature curves in protein folding and macromolecular interactions / Vince J. LiCata and Chin-Chi Liu -- 10. Application of the sequential n-step kinetic mechanism to polypeptide translocases / Aaron L. Lucius, Justin M. Miller, and Burki Rajendar -- 11. A coupled equilibrium approach to study nucleosome thermodynamics / Andrew J. Andrews and Karolin Luger -- 12. Quantitative methods for measuring DNA flexibility in vitro and in vivo / Justin P. Peters, Nicole A. Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahn, and L. James Maher III.

Summary: The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.

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Includes bibliographical references and indexes.

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.

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