Biological mass spectrometry [electronic resource] / edited by A.L. Burlingame.

Includes bibliographical references and index.

Mass spectrometers for the analysis of biomolecules / Michael A. Baldwin -- Hybrid quadrupole/time-of-flight mass spectrometers for analysis of biomolecules / Werner Ens and Kenneth G. Standing -- Tandem time-of-flight mass spectrometry / Marvin L. Vestal and Jennifer M. Campbell -- Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers / Anne H. Payne and Gary L. Glish -- Collision-induced dissociation (CID) of peptides and proteins / J. Mitchell Wells and Scott A. McLuckey -- Peptide sequencing by MALDI 193-nm photodissociation TOF MS / Joseph W. Morgan, Justin M. Hettick, and David H. Russell -- Peptide sequence analysis / Katalin F. Medzihradszky -- Proteomics / John T. Stults and David Arnott -- Bioinformatic methods to exploit mass spectrometric data for proteomic applications / Robert J. Chalkley, Kirk C. Hansen, and Michael A. Baldwin -- Protein conformations, interactions, and H/D exchange / Claudia S. Maier and Max L. Deinzer -- Ligand-metal ion binding to proteins: investigation by ESI mass spectrometry / Noelle Potier ... [et al.] -- Site-specific hydrogen exchange of proteins: insights into the structures of amyloidogenic intermediates / Zhong-Ping Yao, Paula Tito, and Carol V. Robinson -- Quantitating isotopic molecular labels with accelerator mass spectrometry / John S. Vogel and Adam H. Love -- Accelerator mass spectrometry for biomedical research / Karen Brown, Karen H. Dingley, and Kenneth W. Turteltaub.

Description based on print version record.

This volume describes and integrates the techniques and fundamentals of more than a decade of revolutionary advances in both chromatographic and mass spectrometric technologies that have enabled the direct investigation of biomacromolecules per se and have provided the analytical power base to usher in the new fields of proteomics and systems biology. It also covers new biophysical applications such as H/D exchange for study of conformations, protein-protein and protein-metal and ligand interactions. Finally it describes atto-to-zepto-mole quantitation of 14C and 3H by accelerator mass spectrometry. *Part 1 of 2 volumes about Mass Spectrometry *Authoritative and comprehensive treatment of protein mass spectrometry in human cell biology *Presents fundamentals, techniques, instrumentation and bioinformatics *Provides an overview of proteomics, protein-protein and protein-ligand binding, and biophysical studies.