Genomics in cancer drug discovery and development [electronic resource] / edited by Garret M. Hampton, Karol Sikora.

Includes bibliographical references and index.

Contributors to Volume 96 -- Introduction / Garret M. Hampton, Karol Sikora -- Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches / Samuel C. Mok, Kevin M. Elias, Kwong-Kwok Wong, Kae Ho, Tomas Bonome, and Michael J. Birrer -- Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics / Da-Elene van der Merwe, Katerina Oikonomopoulou, John Marshall, and Eleftherios P. Diamandis -- Microarrays to Identify New Therapeutic Strategies for Cancer / Christopher Sears and Scott A. Armstrong -- The Application of siRNA Technology to Cancer Biology Discovery / Uta Fuchs and Arndt Borkhardt -- Ribozyme Technology for Cancer Gene Target Identification and Validation / Qi-Xiang Li, Philip Tan, Ning Ke, and Flossie Wong-Staal -- Cancer Cell-Based Genomic and Small Molecule Screens / Jeremy S. Caldwell -- Tumor Antigens as Surrogate Markers and Targets for Therapy and Vaccines / Angus Dalgleish and Hardev Pandha -- Practices and Pitfalls of Mouse Cancer Models in Drug Discovery / Andrew L. Kung -- Pharmacodynamic Biomarkers for Molecular Cancer Therapeutics / Debashis Sarker and Paul Workman -- Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development: Quantification of Emerging Protein Biomarkers / Jean W. Lee, Daniel Figeys, and Julian Vasilescu -- Molecular Optical Imaging of Therapeutic Targets of Cancer / Kostantin Sokolov, Dawn Nida, Michael Descour, Alicia Lacy, Matthew Levy, Brad Hall, Su Dharmawardhane, Andrew Ellington, Brian Korgel, and Rebecca Richards-Kortum -- Personalized Medicine for Cancer: From Molecular Signature to Therapeutic Choice / Karol Sikora -- Cancer Drug Approval in the United States, Europe, and Japan / R.A.V. Milsted -- Index.

Description based on print version record.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development - Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.