Neurochemical characterization and regulation of CART-containing neural pathways (Record no. 36513)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02151nam a22002297a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | NISER |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251124152556.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251121b |||||||| |||| 00| 0 hin d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NISER LIBRARY |
| Language of cataloging | eng |
| Transcribing agency | NISER LIBRARY |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.8 |
| Item number | BAS-N |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Basu, Sumela |
| 245 ## - TITLE STATEMENT | |
| Title | Neurochemical characterization and regulation of CART-containing neural pathways |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Bhubaneswar : |
| Name of publisher, distributor, etc. | NISER, |
| Date of publication, distribution, etc. | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xi, 308 pages |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Neuropeptide CART is highly expressed in the CNS and is known for its remarkable potential to reconfigure neural circuits for behavioral demands. The functional significance of CART and how it operates the neural circuits to drive behavior are poorly understood. I explored the neurochemicals and signaling systems employed by CART neurons, determined the mechanism through which CART-containing systems drive behavior, and identified the conserved CARTergic neuroanatomical substrates. Three subtypes of CART neurons were observed in the hypothalamus. Secretagogin, highly expressed in the entopeduncular CART neurons, mediates the effect of insulin. CART drives the nigrostriatal DA pathway and motor coordination via the activation of TRPV2. Although CART is highly expressed in each node of the aggression circuit in male as well as female rats, a subset of CART neurons in the hypothalamic attack area drives maternal but not inter-male aggression. CART peptides and the neuroanatomy of CART-containing elements in the brain showed conserved features. Unlike mammals, CART neurons were found in two distinct subdivisions in the arcuate nucleus of a reptile. This study identifies a novel role of CART in driving aggressive actions. CART may influence neural circuits and behavior directly or via modulation of the DA-/glutamatergic pathways, and may serve as a preferred central regulator in the CNS across vertebrates. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | CART (Neuropeptides) |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neuropeptides |
| General subdivision | Physiological effect |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurotransmitters |
| General subdivision | Regulation |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Singru, Praful |
| Relator code | Guide |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://idr.niser.ac.in/jspui/handle/123456789/1488">https://idr.niser.ac.in/jspui/handle/123456789/1488</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Theses (Ph.D) |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Universal Decimal Classification | NISER LIBRARY | NISER LIBRARY | 21/11/2025 | 616.8 BAS-N | T1012 | 21/11/2025 | 21/11/2025 | Theses (Ph.D) |
