Medicinal chemistry of anticancer drugs (Record no. 21019)
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| 000 -LEADER | |
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| fixed length control field | 05268cam a2200697Ia 4500 |
| 001 - CONTROL NUMBER | |
| control field | ocn272382250 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20141103172212.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cn||||||||| |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 081117s2008 ne a ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | |
| Language of cataloging | eng |
| Transcribing agency | OPELS |
| Modifying agency | OPELS |
| -- | OCLCQ |
| -- | OCLCF |
| -- | N$T |
| -- | YDXCP |
| -- | BUF |
| -- | E7B |
| -- | DEBBG |
| -- | I9W |
| 019 ## - | |
| -- | 233578043 |
| -- | 239300330 |
| -- | 646740873 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780444528247 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0444528245 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780080570327 (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0080570321 (electronic bk.) |
| 029 1# - (OCLC) | |
| OCLC library identifier | NZ1 |
| System control number | 13068740 |
| 029 1# - (OCLC) | |
| OCLC library identifier | NZ1 |
| System control number | 15190320 |
| 029 1# - (OCLC) | |
| OCLC library identifier | DEBSZ |
| System control number | 405320205 |
| 029 1# - (OCLC) | |
| OCLC library identifier | CHVBK |
| System control number | 12271668X |
| 029 1# - (OCLC) | |
| OCLC library identifier | CHDSB |
| System control number | 005985913 |
| 029 1# - (OCLC) | |
| OCLC library identifier | DEBBG |
| System control number | BV039831913 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)272382250 |
| Canceled/invalid control number | (OCoLC)233578043 |
| -- | (OCoLC)239300330 |
| -- | (OCoLC)646740873 |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 114030:114121 |
| Source of stock number/acquisition | Elsevier Science & Technology |
| Note | http://www.sciencedirect.com |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC271.C5 |
| Item number | A94 2008eb |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 062000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | HEA |
| Subject category code subdivision | 039030 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.994061 |
| Edition number | 22 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | TEFA |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Avenda�no, Carmen. |
| 245 10 - TITLE STATEMENT | |
| Title | Medicinal chemistry of anticancer drugs |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | Carmen Avenda�no and J. Carlos Men�endez. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Amsterdam ; |
| -- | Boston : |
| Name of publisher, distributor, etc. | Elsevier, |
| Date of publication, distribution, etc. | 2008. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (xv, 442 p.) : |
| Other physical details | ill. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Antitumour chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells. These therapies are in their infancy, but they hold promise of more effective therapies with fewer side effects. Resistance to antitumour drugs is another important but normally neglected field. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumour drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumour agents, aiming at the rationalization of the action of this type of drugs, which would allow the design of new active structures. * Presents information in a clear and concise way using a large number of figures * Historical background provides insights on how the process of drug discovery in the anticancer field has evolved * Extensive references to primary literature. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1. Introduction to anticancer chemotherapy -- 2. Antimetabolites -- 3. Anticancer drugs that inhibit hormone action -- 4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer. -- 5. DNA alkylating agents -- 6. Alkylating and non-alkylating compounds interacting with the DNA minor groove. -- 7. DNA intercalation and inhibition of topoisomerases -- 8. Anticancer drugs targeting tubulin and microtubules -- 9. Drugs targeting signaling pathways for tumour cell growth and proliferation -- 10. Other approaches to targeted therapy -- 11. Drug targeting in anticancer chemotherapy -- 12. Resistance to antitumour agents and drugs that modulate it -- 13. Cancer chemoprevention. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Introduction -- Antimetabolites -- Anticancer drugs that inhibit hormone action -- Anticancer drugs acting via radical species, photosensitizers and photodynamic therapy of cancer -- DNA alkylating agents -- Alkylating and non-alkylating compounds interacting with the DNA minor groove -- DNA intercalators and topoisomerase inhibitors -- Anticancer drugs targeting tubulin and microtubules -- Drugs that inhibit signalling pathways for tumor cell growth and proliferation -- Other approaches to targeted therapy -- Drug targeting in anticancer chemotherapy -- Drugs that modulate resistance to antitumor agents -- Cancer chemoprevention. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Description based on print version record. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer |
| General subdivision | Chemotherapy. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Design. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmaceutical chemistry. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer |
| General subdivision | Chemotherapy. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00845327 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Drugs |
| General subdivision | Design. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst00898790 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmaceutical chemistry. |
| Source of heading or term | fast |
| Authority record control number | (OCoLC)fst01060115 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | MEDICAL |
| General subdivision | Oncology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | HEALTH & FITNESS |
| General subdivision | Diseases |
| -- | Cancer. |
| Source of heading or term | bisacsh |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Men�endez, J. Carlos |
| Fuller form of name | (Jos�e Carlos) |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Avenda�no, Carmen. |
| Title | Medicinal chemistry of anticancer drugs. |
| Edition | 1st ed. |
| Place, publisher, and date of publication | Amsterdam ; Boston : Elsevier, 2008 |
| International Standard Book Number | 9780444528247 |
| -- | 0444528245 |
| Record control number | (OCoLC)227271605 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | ScienceDirect |
| Uniform Resource Identifier | <a href="http://www.sciencedirect.com/science/book/9780444528247">http://www.sciencedirect.com/science/book/9780444528247</a> |
| 938 ## - | |
| -- | ebrary |
| -- | EBRY |
| -- | ebr10225037 |
| 938 ## - | |
| -- | EBSCOhost |
| -- | EBSC |
| -- | 227593 |
| 938 ## - | |
| -- | YBP Library Services |
| -- | YANK |
| -- | 2816701 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | E(electronic)-Books |
| 994 ## - | |
| -- | C0 |
| -- | TEF |
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